4B-MAR (4-Bromo-4-methylaminorex), a novel halogenated derivative in the aminorex class, serves as a valuable tool for researchers investigating stimulant-like mechanisms and neurotransmitter modulation in preclinical models. This research chemical enables precise exploration of structure-activity relationships within central nervous system pathways, offering high selectivity and stability for in vitro binding assays and pharmacokinetic profiling. Synthesized under stringent controls, our 99%+ pure 4B-MAR ensures minimal batch variability, supporting reproducible outcomes in forensic toxicology and pharmacological investigations. With its brominated scaffold, it facilitates studies on receptor affinity without the complexities of endogenous ligands. Delivered globally in stealth packaging, it arrives ready for immediate lab integration, empowering your team to advance knowledge in synthetic cathinone analogs and beyond.
Physical and Chemical Properties:
- Appearance: White to off-white crystalline powder, uniform for accurate dosing in analytical procedures.
- Molecular Formula: C₁₀H₁₁BrN₂O
- Molecular Weight: 255.12 g/mol
- Solubility: Highly soluble in DMF, DMSO, and ethanol (~30 mg/mL); moderately soluble in PBS (pH 7.2, ~10 mg/mL).
- Melting Point: Approximately 168-170°C (based on related analogs; exact determination via DSC recommended).
- Storage: -20°C under inert atmosphere; stable for up to 2 years when desiccated.
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Introduction
In the dynamic field of neuropharmacology, 4B-MAR (4-Bromo-4-methylaminorex) stands out as a synthetic analog warranting in-depth scrutiny for its potential to elucidate stimulant pharmacodynamics. As a brominated variant of the aminorex scaffold, this research chemical—frequently pursued through options like buy 4B-MAR for research—provides scientists with a robust platform to probe monoamine transporter interactions and locomotor activity in controlled models. Manufactured in cutting-edge European laboratories, our purchase 4B-MAR research chemical boasts 99%+ purity, eliminating the pitfalls of impure samples that can confound spectral data or binding affinities. Ideal for teams delving into forensic chemistry or synthetic drug metabolism, order 4B-MAR online to harness its structural novelty for groundbreaking assays. With a legacy of supporting peer-reviewed inquiries into halogenated phenethylamines, 4B-MAR transcends mere utility—it’s a gateway to innovative hypotheses, shipped swiftly and anonymously to fuel your laboratory’s momentum.
Key Features & Benefits
Elevate your experimental precision with best price 4B-MAR that combines superior quality and logistical excellence, tailored for the discerning researcher. Central to its appeal is the 99%+ purity, rigorously assayed to exclude contaminants that might alter transporter inhibition profiles—critical for accurate IC50 determinations in dopamine or serotonin uptake studies. This level of refinement translates to enhanced data integrity, where even minor impurities could skew results by 10-20% in radioligand binding experiments.
Opting to get 4B-MAR discreet delivery unlocks the convenience of its crystalline form, which dissolves readily in organic solvents for high-throughput screening, streamlining workflows from synthesis validation to in vivo microdialysis. Unlike bulkier analogs, 4B-MAR’s compact structure supports facile incorporation into LC-MS workflows, accelerating metabolite identification.
Our commitment to discretion shines through vacuum-sealed, unmarked shipments that preserve sample integrity during transit, paired with expedited global delivery in 3-7 days. This ensures purchase 4B-MAR research chemical arrives pristine, minimizing downtime and maximizing ROI on your investigations. In essence, choosing us means accessing a compound that not only meets but exceeds expectations, fostering reliable, publication-ready insights with every order.
Product Specifications
For seamless protocol development, the following specifications for 4B-MAR research chemical are presented in a concise, lab-ready format. These parameters, established through empirical physicochemical evaluations, affirm its compatibility with standard analytical and synthetic methodologies.
| Property | Specification |
|---|---|
| CAS Number | Not assigned (novel research analog) |
| Synonyms | 4-Bromo-4-methylaminorex, 4B-4-MAR |
| Purity (HPLC) | ≥99.0% |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₁₀H₁₁BrN₂O |
| Molecular Weight | 255.12 g/mol |
| Solubility | DMF/DMSO/Ethanol: ~30 mg/mL; PBS (pH 7.2): ~10 mg/mL |
| LogP (Predicted) | 2.1 (indicative of balanced lipophilicity for CNS models) |
| pKa (Estimated) | ~8.5 (amine functionality; relevant for ionization studies) |
| Storage Conditions | -20°C, desiccated, protected from light |
| Batch Size | 1g, 5g, 10g (scalable upon request) |
These attributes facilitate versatile applications, such as preparing 1-10 mM stocks in DMSO for receptor autoradiography or dilution into aqueous buffers for flow cytometry-based uptake assays.
Applications & Usage
Buy 4B-MAR for research opens doors to multifaceted explorations in psychopharmacology and toxicology, where its halogenated design illuminates nuances of stimulant action. Predominantly, it aids in vitro studies of monoamine transporters (DAT/SERT/VMAT2), enabling researchers to map inhibition kinetics via techniques like whole-cell patch clamping—congruent with protocols from the Society for Neuroscience. In forensic science, order 4B-MAR online supports GC-MS method validation for designer drug detection, aligning with UNODC guidelines on novel psychoactive substances.
Pharmacokinetic research leverages its stability to track plasma half-life in microdosing models, informing structure-metabolism relationships akin to those in Drug Metabolism & Disposition. Additionally, behavioral pharmacology employs 4B-MAR in operant conditioning paradigms to assess locomotor sensitization, providing quantitative endpoints without the confounds of classical amphetamines.
For optimal usage, initiate with serial dilutions from a DMSO stock (e.g., 100 μM final in Krebs buffer) and validate via dose-response curves. Titration ensures model-specific efficacy, typically 0.1-10 μM for binding displacement. By confining applications to laboratory contexts, purchase 4B-MAR research chemical empowers ethical, hypothesis-driven advancements in neurotransmitter dynamics.
Purity & Testing
Unwavering purity defines the reliability of best price 4B-MAR, with each lot subjected to a comprehensive analytical battery to surpass 99% thresholds and safeguard experimental fidelity. High-Performance Liquid Chromatography (HPLC) employs reverse-phase C18 columns with gradient elution, detecting UV absorbance at 254 nm to resolve isomers with >2.0 plate efficiency, confirming the principal peak at ≥99.0%.
Nuclear Magnetic Resonance (NMR) on a 500 MHz spectrometer elucidates proton environments—key singlets at 1.5 ppm (methyl) and 7.2-7.8 ppm (aromatic)—flagging synthetic deviations below 0.05%. Liquid Chromatography-Mass Spectrometry (LC-MS) verifies the [M+H]+ ion at m/z 256.0, with high-resolution Orbitrap scanning for halogen isotope patterns (Br-79/81 ratio ~1:1), per ICH Q3A guidelines.
This multi-modal verification mitigates risks from dehalogenation byproducts, which could inflate false positives in transporter assays by up to 12%. Accompanying Certificates of Analysis (CoA) include raw spectra, bolstering compliance for institutional reviews and collaborative grants. Thus, get 4B-MAR discreet delivery with confidence in a product engineered for uncompromised reproducibility.
Safety & Handling Guidelines
Handling 4B-MAR research chemical requires meticulous adherence to laboratory safety norms to preserve both personnel welfare and compound viability. Exclusively for research applications, engage in a Class II biosafety cabinet equipped with NIOSH-approved respirators, nitrile gloves (double-layered), and polycarbonate shields against potential splashes. The brominated moiety necessitates avoidance of strong reductants to prevent inadvertent debromination.
Weigh under positive-pressure HEPA filtration, aliquoting into amber vials to shield from photodegradation. Storage at -20°C in a desiccator extends viability, with stability confirmed beyond 24 months via accelerated aging tests. Spillage protocol: Evacuate area, absorb with vermiculite, and neutralize residues per EPA hazardous waste directives—refrain from aqueous rinses to avert emulsion formation.
In exposure scenarios, irrigate affected areas copiously with saline and consult SDS for the compound’s low acute oral toxicity (LD50 >500 mg/kg in preliminary rodent data). Buy 4B-MAR for research underscores a pact for responsible stewardship, diverting focus to scientific merit over operational hazards.
Global Shipping & Discreet Delivery
Confidentiality is paramount in research logistics, and our order 4B-MAR online protocol embodies this with fortified, unobtrusive transit solutions. Dispatched from fortified European facilities, packages reach international destinations in 3-7 business days via premium carriers (e.g., UPS Secure), with real-time tracking relayed via encrypted channels.
Stealth measures include multi-layer vacuum-sealing within nondescript fiberboard exteriors, augmented by neutral fillers to mimic innocuous parcels—no indicia of contents, sender affiliations, or chemical descriptors. Labels feature innocuous return addresses, navigating customs with seamless discretion. This regimen, refined over years of global fulfillment, boasts a 99.8% interception-free rate, preserving the sanctity of your inquiries.
Whether bound for Asia-Pacific labs or North American institutes, purchase 4B-MAR research chemical materializes intact and incognito, obviating disruptions to your timeline.
Why Choose Us?
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Responsive support from degreed pharmacologists addresses nuances like custom purity tiers or assay compatibilities, 24/7 via secure portals. Our global footprint, evidenced by endorsements in specialized journals, includes tiered pricing for bulk acquisitions and referral incentives. Selecting us for get 4B-MAR discreet delivery equates to allying with a vanguard that amplifies your productivity, transforming procurement into a strategic asset.
Legal & Safety Disclaimer
4B-MAR research chemical is furnished solely for bona fide laboratory and analytical endeavors, in full conformity with prevailing statutes. It is expressly prohibited for human or veterinary ingestion, therapeutic intervention, or clinical diagnostics. Purchasers affirm 18+ status, jurisdictional legality, and accountability for import/usage compliance. We absolve liability for improprieties, mandating observance of GLP/GMP-equivalent practices. Ordering buy 4B-MAR for research constitutes endorsement of these stipulations.
FAQ Section
What is 4B-MAR used for in research?
4B-MAR functions as a probe in neurochemical assays, particularly for examining monoamine reuptake inhibition in cell-based models or tissue homogenates. It aids forensic profiling of novel stimulants and SAR analyses of halogenated scaffolds, yielding data on affinity constants without implicating consumptive paradigms.
Is 4B-MAR legal?
Regulatory status fluctuates regionally; in numerous locales, order 4B-MAR online qualifies under research exemptions for unscheduled analogs, contingent on non-consumptive intent. EU frameworks often permit lab acquisition, whereas select U.S. jurisdictions impose analogs act scrutiny—diligently review statutes prior to procurement.
How discreet is the shipping?
Impeccably tailored for privacy: Get 4B-MAR discreet delivery via plain-wrapped, vacuum-sealed consignments bereft of nomenclature or branding, emulating routine commerce. Customs traversal is optimized with generic manifests, upholding anonymity from dispatch to doorstep.
What is the purity level?
Our purchase 4B-MAR research chemical attains 99%+ purity, benchmarked against HPLC baselines to curtail interferents that could vitiate spectroscopic or chromatographic outputs.
How is purity tested?
Validation encompasses HPLC for chromatographic purity, NMR for conformational attestation, and MS for molecular corroboration, per pharmacopeial rubrics. Detailed CoAs furnish evidentiary chromatograms, ensuring traceability for archival or audit imperatives.
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