Advance your neurochemical and pharmacological research with our premium 2F-DCK HCl (2-Fluorodeschloroketamine), a water-soluble hydrochloride salt of the fluorinated ketamine analog, designed for precise studies of NMDA receptor antagonism and dissociative mechanisms. This compound, ideal for exploring arylcyclohexylamine structure-activity relationships, delivers unmatched consistency for laboratory applications. Our 2F-DCK HCl for research achieves 99%+ purity through rigorous purification, ensuring minimal impurities for accurate results in techniques like LC-MS or neuronal assays. Available as a fine crystalline powder, it’s optimized for solubility and dosing precision. Buy 2F-DCK HCl (2-fluorodeschloroketamine)

Physical and Chemical Properties:

• Appearance: White to off-white crystalline powder, fine and uniform
• Molecular Formula: C13H16FNO·HCl
• Molecular Weight: 257.73 g/mol (HCl salt)
• Solubility: Highly soluble in water (~50 mg/mL at pH 5), DMSO (>100 mg/mL), and ethanol
• Melting Point: 175-180°C (HCl salt)
• Purity Level: 99.5%+ confirmed by HPLC and LC-HRMS
• CAS Number: 111982-49-1 (HCl salt)
• Storage: Store in amber vials under inert gas at 2-8°C to maintain stability

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Introduction

In the evolving field of neuropharmacology and synthetic chemistry, 2F-DCK HCl (2-Fluorodeschloroketamine hydrochloride) stands as a cornerstone for researchers investigating dissociative anesthetics and arylcyclohexylamine analogs. This fluorinated derivative of ketamine, featuring a 2-fluorophenyl group and a water-soluble hydrochloride moiety, has gained traction since its research debut around 2016 for its utility in probing NMDA receptor interactions and metabolic pathways. Its enhanced solubility compared to the free base makes it ideal for aqueous-based assays, offering precision in dosing for studies of synaptic modulation or forensic profiling.

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Key Features & Benefits

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• Superior 99%+ Purity: Rigorously purified to eliminate trace contaminants, our 2F-DCK HCl ensures clarity in high-sensitivity analyses like LC-HRMS or electrophysiology, delivering consistent, reproducible data.
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Product Specifications

Our commitment to analytical excellence is reflected in the precise specifications of 2F-DCK HCl, aligned with standards from the International Council for Harmonisation (ICH) to support your experimental needs. These details ensure compatibility with advanced analytical techniques:

Property	Specification
Molecular Structure	2-(2-Fluorophenyl)-2-(methylamino)cyclohexan-1-one hydrochloride
Purity	≥99.5% (HPLC, HCl salt)
Particle Size	20-60 μm (optimized for dissolution)
Density	1.15 g/cm³ (HCl salt)
UV-Vis Absorption	λ_max 260 nm (aryl ketone signature)
Stability	Stable for 24 months under refrigeration; protect from light and moisture
Packaging Options	500mg, 1g, 5g in tamper-evident amber vials

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Applications & Usage

2F-DCK HCl is a versatile tool for studying dissociative pharmacophores, particularly in elucidating fluorine’s impact on NMDA receptor affinity and downstream signaling. Neuropharmacologists employ 2F-DCK HCl for research in patch-clamp assays to assess channel inhibition, adhering to protocols from the International Union of Basic and Clinical Pharmacology (IUPHAR). Forensic scientists leverage it for HRMS-based NPS detection, as outlined in Forensic Science International, enhancing identification of novel analogs.

Synthetic chemists use 2F-DCK HCl to explore fluorination effects on cyclohexanone scaffolds, while toxicologists study its metabolism (e.g., N-demethylation via CYP2B6). For optimal use, dissolve in deionized water or DMSO to 20 mM stock solutions, then dilute into physiological buffers; chiral HPLC can resolve enantiomers for stereospecific studies. Our product excels in these contexts, ensuring robust outcomes for peer-reviewed research. Strictly for laboratory use, always follow institutional safety protocols and the provided SDS.

Purity & Testing

Purity is the bedrock of reliable research, and our 99% pure 2F-DCK HCl undergoes a comprehensive analytical suite to confirm its exceptional quality. High-performance liquid chromatography (HPLC) quantifies impurities at 220 nm, while liquid chromatography-high-resolution mass spectrometry (LC-HRMS) verifies molecular identity and fluorine substitution (¹J_C-F ≈240 Hz). Nuclear magnetic resonance (NMR) spectroscopy confirms structural fidelity, detecting contaminants below 0.05% via peak integration.

Aligned with ICH Q3A guidelines, these tests minimize variability in applications like receptor binding studies or metabolite tracking, enhancing data integrity. Each buy 2F-DCK HCl for research order includes a certificate of analysis (CoA) with detailed chromatograms and spectra, supporting your documentation needs. In a field demanding precision, our testing regimen for 99% pure 2F-DCK HCl ensures your experiments are built on a foundation of trust.

Safety & Handling Guidelines

Handling arylcyclohexylamines like 2F-DCK HCl requires stringent safety measures, and we provide detailed protocols to mitigate risks. As a crystalline powder, it poses potential inhalation or dermal absorption hazards—handle in a Class II biosafety cabinet with HEPA filtration, using PPE including N95 respirators, nitrile gloves, and safety goggles.

In case of exposure, rinse affected areas with water for 15 minutes and seek medical attention; use activated charcoal for suspected ingestion. Store under inert gas at 2-8°C to prevent degradation, and dispose of waste via high-temperature incineration per local regulations (e.g., EPA or EU equivalents). This product is for research use only—not for human or animal consumption, diagnostics, or non-scientific purposes. Buyers (18+) must ensure compliance with all applicable laws; misuse voids warranties and assumes full liability.

Global Shipping & Discreet Delivery

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Legal & Safety Disclaimer

2F-DCK HCl is supplied exclusively for legitimate laboratory research and is not approved for human or veterinary use, consumption, or therapeutic applications. Buyers must be 18+ and confirm compliance with local, national, and international regulations governing research chemicals. We disclaim liability for misuse, and purchasers indemnify us against claims arising from improper handling. Consult legal experts for jurisdiction-specific guidance, and refer to the provided SDS for comprehensive hazard information.

FAQ

What is 2F-DCK HCl Used for in Research?

2F-DCK HCl (2-Fluorodeschloroketamine hydrochloride) is vital in 2F-DCK HCl for research, enabling studies of NMDA receptor antagonism and fluorine’s effects on dissociative pharmacodynamics. It supports forensic NPS profiling and metabolic studies, per EMCDDA standards, strictly for laboratory use.

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As a research chemical, 99% pure 2F-DCK HCl is permissible for scientific purchase in many regions when used in accredited labs. Regulations vary; we provide export documentation to support compliant purchase 2F-DCK HCl research chemical transactions—verify local laws.

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Our 99% pure 2F-DCK HCl achieves ≥99.5% purity, validated by independent testing to eliminate impurities that could affect experimental precision. This ensures the best price 2F-DCK HCl lab grade delivers reliable performance.

How Is Purity Tested for 2F-DCK HCl?

Purity is verified via HPLC for impurity quantification, LC-HRMS for molecular and isotopic confirmation, and NMR for structural validation, adhering to ICH standards. The CoA with your buy 2F-DCK HCl for research order provides detailed analytical data.