Elevate your pharmacological and neurochemical investigations with our high-purity Alprazolam 0.25mg blotters, a triazolobenzodiazepine analog precisely dosed for studies of GABA-A receptor modulation and anxiolytic mechanisms. This research chemical, structured as 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, facilitates detailed explorations of sedative-hypnotic effects and metabolic pathways in controlled lab settings. Our Alprazolam for research guarantees 99%+ purity through stringent refinement, minimizing impurities that could skew results in assays like LC-MS or radioligand binding, making it indispensable for scientists advancing benzodiazepine analog research.

Physical and Chemical Properties:

• Appearance: White perforated blotter paper squares, uniform 0.25mg per tab
• Molecular Formula: C17H13ClN4
• Molecular Weight: 308.76 g/mol
• Solubility: Soluble in DMSO (>50 mg/mL) and ethanol; sparingly soluble in water (~1 mg/mL at pH 7)
• Melting Point: 228-229.5°C
• Purity Level: 99.5%+ confirmed by HPLC and GC-MS
• CAS Number: 28981-97-7
• Storage: Sealed in amber foil under inert atmosphere at 2-8°C to prevent degradation

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Introduction

In the intricate domain of benzodiazepine pharmacology and central nervous system research, Alprazolam 0.25mg blotters emerge as a foundational tool, providing researchers with a standardized platform for dissecting triazolobenzodiazepine mechanisms. This potent compound, featuring a fused triazolo ring with a 2-fluorophenyl substituent, has been a staple in studies since its synthesis in the 1970s, enabling precise inquiries into GABA-A receptor allosteric modulation and short-acting anxiolytic profiles. The blotter format ensures uniform 0.25mg dosing, ideal for dose-response modeling in preclinical assays.

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Product Specifications

Our Alprazolam 0.25mg blotters are meticulously specified to align with international standards like those from the International Council for Harmonisation (ICH), ensuring compatibility with your analytical protocols. Below is a detailed profile:

Property	Specification
Molecular Structure	8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-α][1,4]benzodiazepine (triazolobenzodiazepine)
Purity	≥99.5% (HPLC, free base equivalent)
Dosage Format	0.25mg ± 5% per blotter (25-tab sheet, 5×5 grid)
Blotter Size	0.5 cm² per tab (perforated for easy separation)
UV Absorption	λ_max 220 nm and 308 nm (characteristic benzodiazepine bands)
Stability	Stable for 24 months under refrigeration; moisture-sensitive
Packaging Options	25-tab sheets; bulk 100/500 tabs in foil pouches

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Applications & Usage

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Synthetic chemists value the blotter format for stability in analog derivatization, while toxicologists map its CYP3A4-mediated hydroxylation in microsomal models. For usage, dissolve tabs in DMSO or ethanol via sonication to achieve 1 mM stocks, then dilute into buffered media; calibrate with standards for quantitative precision. Our product performs consistently in these contexts, fostering peer-reviewed advancements. Exclusively for laboratory applications, consult institutional safety data sheets (SDS) for protocol integration.

Purity & Testing

Purity is the bedrock of credible research, and our 99% pure Alprazolam 0.25mg blotters undergo a multi-tiered analytical validation to confirm their excellence. High-performance liquid chromatography (HPLC) quantifies impurities at 220 nm, while gas chromatography-mass spectrometry (GC-MS) verifies molecular identity (m/z 309 [M+H]+). Nuclear magnetic resonance (NMR) spectroscopy authenticates the triazolo structure, detecting trace degradants below 0.05% via peak integration.

Compliant with ICH Q3A guidelines, these methods reduce variability in applications like receptor affinity assays or pharmacokinetic modeling, enhancing data robustness. Each buy Alprazolam 0.25mg blotters for research order includes a certificate of analysis (CoA) with chromatograms and spectra, bolstering your grant proposals and publications. In a field where precision is paramount, our testing protocol for 99% pure Alprazolam ensures your work’s integrity.

Safety & Handling Guidelines

Safety remains paramount when engaging with benzodiazepines like Alprazolam 0.25mg blotters, and we furnish comprehensive protocols to mitigate risks. As scored tabs, they require handling in a well-ventilated fume hood with NIOSH-approved respirators, nitrile gloves, and safety goggles to avoid inhalation or dermal contact.

In case of exposure, rinse affected areas with water for 15 minutes and seek medical evaluation; activated charcoal may be used for suspected ingestion. Store in a desiccated, inert environment at 2-8°C to avert hydrolysis, and dispose of waste via incineration per local regulations (e.g., EPA standards). This product is for research use only—not intended for human or animal consumption, therapeutic trials, or non-scientific purposes. Users (18+) must affirm compliance with all applicable laws; mishandling voids warranties and assumes full liability.

Global Shipping & Discreet Delivery

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Legal & Safety Disclaimer

Alprazolam 0.25mg blotters are supplied strictly for legitimate laboratory research purposes and are not approved for human or veterinary use, food additives, or any consumptive applications. All buyers must be at least 18 years of age and verify compliance with local, national, and international regulations governing research chemicals. We disclaim any liability for misuse, and purchasers agree to indemnify us against claims arising from improper handling. Consult legal counsel for jurisdiction-specific advice, and always reference the provided SDS for hazard information.

FAQ

What is Alprazolam 0.25mg Blotters Used for in Research?

Alprazolam 0.25mg blotters, or Alprazolam for research, are harnessed to investigate GABA-A receptor modulation, anxiolytic pharmacodynamics, and benzodiazepine metabolism in models of CNS inhibition, per IUPHAR standards, strictly for laboratory applications.

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We guarantee ≥99% purity for 99% pure Alprazolam, substantiated by third-party analytics to preclude interferents. This lab-grade threshold ensures the best price Alprazolam lab grade excels in experimental designs.

How Is Purity Tested for Alprazolam 0.25mg Blotters?

Purity is assessed using HPLC for chromatographic profiling, GC-MS for mass spectral confirmation, and NMR for structural verification—methods mirroring ICH Q3A standards. These provide the CoA with your buy Alprazolam 0.25mg blotters for research, certifying integrity.